Studies on squamous metaplasia in rat bladder. II. Effects of estradiol and estradiol plus hexestrol.

different forms of foreign-body irritation and of vitamin A deficiency to squamous metaplasia in the bladders of rats was reported. It is also known that estrogens will cause squamous metaplasia. The metaplasia following estrogen administration has been described in various organs of the genito urinary system in different species (SO). It has been found in the uterus (@,17, 19), and the mets plastic effect of estrogens in the male has also been described for the prostate (14). In this paper we are concerned with the effects of estradiol and the combination of estradiol and the synthetic estrogen hexestrol with vitamin A deficiency and irritative. foreign body stimulation on metaplasia in the bladder.